Menopause guide
A guide to perimenopause and menopause

Your last period doesn't announce itself. You only know a year later.

If you are 45 or over, otherwise healthy, have typical symptoms and are not using hormonal contraception, menopause is recognised after at least 12 months without a period. Symptoms can be treated before that.

Start from a period ontoday, or any date you choose

The pill, the implant or a hormonal coil can change bleeding, and after a hysterectomy there are no periods to count: then a doctor looks at symptoms, age and history. Before 45, the assessment is different.

Educational information based on guidance from The UK National Institute for Health and Care Excellence. It publishes clinical guidance based on evidence assessment. and The European Society of Endocrinology, a professional medical society that publishes guidance on hormones and endocrine glands.. Sources rechecked on 27 September 2026. No independent clinical review.

First, the essentials.

Perimenopause and menopause describe stages of the same biological process. The experience, duration and need for treatment vary greatly between people.

What changes in the body

The ovaries gradually release fewer eggs, while hormone levels fluctuate and then fall. This can change cycles and cause symptoms affecting temperature regulation, sleep, mood, vaginal tissues, muscles and bones.

When and why it can happen

Menopause usually happens between ages 45 and 55. It can happen earlier spontaneously, after the ovaries are removed, chemotherapy or radiotherapy; sometimes the cause remains unknown.

What you can do now

Track symptoms and cycles. Regular sleep, physical activity including strength exercise, a balanced diet and identifying hot-flush triggers may help. Discuss supplements with a doctor or pharmacist, and ask for help when symptoms affect your life.

The 90-second map

Perimenopause, menopause, postmenopause: a few landmarks.

The transition varies greatly between people. The calendar helps with definitions; symptoms and their impact guide the conversation about care.

before point zero

Perimenopause

Perimenopause is the beginning of the transition. Cycles may change and symptoms can begin years before the final menstrual period.

day zero, recognised only later

Final menstrual period

On the day it happens there is no certain label. Confirmation comes after 12 months, in the absence of another explanation.

after 12 months

Menopause

The term describes this clinical landmark. Hormonal contraception, hysterectomy and some treatments can make the calendar harder to interpret.

the years that follow

Postmenopause

Some symptoms ease and others continue. Bone, cardiovascular, sexual and urinary health remain part of routine care.

You can ask for help before 12 months.Treatment can be discussed for symptoms and their impact without waiting for menopause to be confirmed.
Pregnancy remains possible in perimenopause.Hormone replacement therapy: treatment with oestrogen, sometimes combined with a progestogen. is not contraception. Contraceptive needs are discussed separately.
Menopause can happen earlier.Ages 40–44 are classed as early menopause; under 40, premature ovarian insufficiency is assessed.
What matters for diagnosis

The FSH test: its role depends on age.

A single hormone result may capture one day in a fluctuating process. History, cycles, symptoms and medical context are essential.

45+

Usually a clinical diagnosis

In otherwise healthy people, NICE recommends identifying perimenopause or menopause from symptoms and cycle changes, without routine laboratory tests.

40–45

Follicle-stimulating hormone, measured with a blood test. Its level can fluctuate during perimenopause. may have a role

At this age FSH can be considered alongside symptoms and cycle changes. Assessment also looks for other possible explanations.

<40

Assess for premature ovarian insufficiency

NICE requires symptoms and two raised FSH results 4–6 weeks apart. One test does not establish the diagnosis.

The dedicated page: what each test says, at each age →

The symptom constellation

Menopause symptoms: there is no single experience.

Choose an area. The guide shows patterns associated with menopause and a useful next topic for an appointment; it does not establish the cause.

12

Ciclul își poate pierde regularitatea.

Menstruațiile pot veni mai devreme sau mai târziu și pot deveni mai ușoare ori mai abundente. Sângerarea neobișnuită are nevoie de evaluare; schimbarea nu trebuie atribuită automat perimenopauzei.

Pentru consultație: notează datele, durata, abundența, cheagurile, durerea și orice sângerare între menstruații sau după contact sexual.

Symptoms can be mild or severe, brief or long-lasting. Some people have few symptoms; others experience major effects on work, relationships and sleep.

The brain in transition

Menopause brain fog has recognisable forms.

Cognitive changes are commonly reported during perimenopause. They are usually mild, but can affect work, confidence and daily life.

Language

The word is on the tip of your tongue

It may take longer to retrieve a familiar word, name or number.

Attention

You lose the thread more easily

Distractions can interrupt a conversation, reading or a task that used to flow naturally.

Working memory

Information does not stay long enough

It can be harder to hold a code, a step or the reason you entered a room briefly in mind.

Verbal memory

Appointments and details slip

You may forget a meeting, a date or part of a recent conversation.

In studies, average performance usually remains within normal limits.

The most consistent changes are in verbal learning and memory; effects on attention and working memory are more modest or less consistent. The experience is real, but brain fog does not establish a dementia diagnosis.

fragmented sleephot flushes and sweatsanxiety or depressionstressmedicinesthyroid disease or anaemia

Treatment addresses symptoms and contributing factors. HRT can be discussed for menopause symptoms when appropriate, but it is not prescribed solely to improve cognition or prevent dementia.

The body in transition

Menopause and weight: the scale shows the total, not the composition.

In midlife, weight, waist, muscle mass and where the body stores fat may change. These changes do not happen in the same way to everyone.

Total weight
It may rise, remain similar or fluctuate. IMS attributes most midlife weight gain to chronological ageing, loss of muscle mass and lower total energy expenditure.
Fat distribution
The decline in oestrogen is associated with a greater proportion of abdominal fat, including visceral fat, and a larger waist, even in some people with a similar weight or BMI.
Muscle mass
It tends to decline with age. Strength, mobility and bone health deserve protection through physical activity, including resistance and weight-bearing exercise.
Metabolic context
Visceral fat is associated with higher risk of diabetes, high blood pressure, abnormal lipids and cardiovascular disease. BMI alone does not capture all of this risk.

Broken sleep, hot flushes, mood, activity, food, medicines and some health conditions can affect weight. A rapid or unexplained change deserves assessment, including for other causes.

Your relationship with your body can change too.

Clothes may fit differently, a familiar shape may change, and that change can affect confidence, sexuality or the wish to be seen. Shame and withdrawal are not requirements of menopause. Persistent low mood, loss of pleasure, severe anxiety or changes in eating deserve discussion with a professional.

The dedicated page: what changes beneath the number on the scale →

Treatment depends on what bothers you

Menopause treatment has several paths.

Treatment is chosen through shared decision-making, based on what bothers you, medical history, anatomy, risks, preferences and local availability.

hot flushes and night sweats

Hormone replacement therapy: treatment with oestrogen, sometimes combined with a progestogen., menopause-specific Cognitive behavioural therapy adapted for menopause symptoms. and nonhormonal options

NICE recommends offering HRT to eligible people with hot flushes or night sweats. CBT can be used with HRT or when HRT is unsuitable or unwanted. Fezolinetant is the active substance and Veoza is the trade name authorised in the European Union. It is a nonhormonal medicine for moderate to severe hot flushes associated with menopause. is a prescription option when HRT is unsuitable and requires liver-function tests before starting, monthly for the first 3 months, then on clinical judgement.

See recommendation
dryness, pain, urinary symptoms

Local treatment may be enough

Low-dose vaginal oestrogen acts locally, with only a minimal amount reaching the bloodstream. Whole-body exposure is much lower than with A systemic treatment travels through the bloodstream and can act in several parts of the body. Its benefits, contraindications and risks are therefore assessed separately from local vaginal treatment. hormone therapy. Vaginal oestrogen can be used alone or with moisturisers and lubricants. A history of breast cancer requires individual discussion, sometimes with the oncology specialist.

See recommendation
sleep, mood, stress

Symptoms and mental health are assessed together

Menopause-specific CBT may help some symptoms. Clinical depression needs its own assessment and treatment; the ESE guideline does not recommend HRT as routine treatment for depression.

See recommendation
bones, muscles, long-term health

Movement, strength and risk assessment still matter

NICE recommends attention to bone health and maintaining muscle mass through physical activity. HRT reduces fracture risk while it is taken, but is not prescribed to prevent dementia or cardiovascular disease.

See recommendation
HRT is a family of decisions

Route, combination and timing matter.

The label ‘hormone therapy’ covers different treatments. Benefits and risks should be discussed for the actual formulation and the actual person.

In the comparisons below, HRT containing oestrogen and a progestogen. The progestogen protects the lining of the uterus from the effects of oestrogen. means oestrogen plus a progestogen.

Uterus presentSystemic oestrogen is combined with a progestogen to protect the endometrium.
Total hysterectomyA progestogen protects the lining of the uterus, called the endometrium, from the effects of oestrogen. After a total hysterectomy there is no uterus, and NICE recommends oestrogen-only HRT. may be offered when HRT is appropriate.
Oral or transdermalNICE says venous thromboembolism risk rises with oral HRT and does not rise with HRT delivered through the skin, usually as a patch, gel or spray. Oestrogen enters the bloodstream through the skin. The route matters because NICE says venous thromboembolism risk does not rise with transdermal HRT, unlike oral HRT.; dose, age and medical history remain relevant.
Local or systemicVaginal oestrogen treats genitourinary symptoms locally; it is not equivalent to systemic treatment for hot flushes.
ContraceptionHRT does not prevent pregnancy. Contraception is decided separately.
Benefits and risks in absolute numbers

Estimated breast cancer cases per 1,000 women.

NICE estimates new cases between ages 50 and 69. Every bar uses the same scale, from 0 to 100 cases per 1,000.

estimated breast cancer cases between ages 50 and 69
no HRToestrogen + progestogenoestrogen only

UK population estimates, not personal predictions. Use starts at age 50 and risk is measured over 20 years. The NICE graph combines continuous and sequential combined regimens.

Composition changes risk

Breast cancer risk rises with combined HRT and with duration. NICE describes little or no increase with oestrogen alone. Sequential combined HRT carries less risk than continuous combined HRT, but more than no HRT.

Route changes other risks

Transdermal treatment matters mainly for blood clots and stroke. It does not remove the effects of composition and duration on breast cancer risk.

Personal risk starts elsewhere

Age, family history, alcohol, weight and medical history change baseline risk. A personal history of breast cancer requires individual discussion, sometimes with the oncology specialist.

The dedicated page: HRT risks counted per 1,000 women →

NICE says evidence is still insufficient to establish whether micronised progesterone or dydrogesterone carries a different breast cancer risk from other progestogens.

HRT is the most effective option for hot flushes and night sweats in eligible people and reduces fracture risk while it is taken. Overall, NICE says HRT is unlikely to affect life expectancy.

Open the full NICE discussion aid
A tool for your appointment

Turn difficult days into a useful clinical story.

Select what you want to discuss. The note is created only on your device; the page does not send or save your answers.

What affects you?
What do you want from the appointment?
When not to wait

Bleeding after menopause and other signs that should not wait.

Menopause is not an automatic explanation for every symptom appearing in midlife.

Call emergency services

Chest pain with breathlessness; facial droop, affected speech or movement; severe bleeding with fainting or severe dizziness; immediate risk of self-harm. A mental health emergency is as serious as a medical emergency.

Seek prompt medical assessment

Any bleeding after at least 12 months without a period (on HRT: unscheduled bleeding after the first 6 months, or after the first 3 months following a dose change), bleeding after sex, very heavy bleeding, new symptoms under 45, or persistent adverse effects after starting treatment.

For partners, family and friends

Supporting someone you love through menopause: it starts with a good question.

Symptoms can affect sleep, concentration, mood, work and sex. The experience may change over time, and useful support is agreed together.

01

Learn the pattern without diagnosing

Read about symptoms and accept that they can vary. Do not automatically attribute every emotion, pain or disagreement to menopause.

02

Protect sleep and take on everyday tasks

A cooler bedroom, separate duvets, a lighter schedule or taking over some tasks may help after broken nights. Ask what would be useful, because the answer differs between people.

03

Talk about intimacy without pressure

Dryness, pain, poor sleep and changes in sexual desire can affect closeness. Affection should not depend on sex; medical options exist for vaginal and sexual symptoms.

04

Help her get to a doctor, if she asks

You can help track symptoms, questions and treatments tried, or attend an appointment. Decisions about their body and treatment belong to the person receiving care.

05

Keep the conversation open

Ask periodically what is working. Symptoms may change, and a solution that helped last month may no longer be enough.

Hormonal changes and sleep loss can affect mood and reactions. They do not justify humiliation, control, coercion or violence. Both partners’ safety remains the priority.

Frequently asked questions

Frequently asked questions about perimenopause and menopause.

Short answers about duration, tests, contraception, HRT, weight, memory and sexual health.

What are the first symptoms, and can they start while I still have periods?

Yes. Perimenopause happens before the final menstrual period, and symptoms may begin while periods continue. If the pattern is unusual or symptoms do not fit, assessment should also look for other causes.

How long do menopause symptoms last?

The NHS estimates that symptoms usually last 7 to 9 years, sometimes longer, and may change over time. Vaginal dryness, urinary symptoms or joint pain can continue after menopause.

How can I tell where I am if I use a hormonal coil or have had a hysterectomy?

Hormonal contraception can make periods irregular or stop them. A hysterectomy stops periods but does not automatically cause menopause if the ovaries remain. A clinician uses age, symptoms, the type of surgery or treatment and, only in selected situations, an FSH test, which measures follicle-stimulating hormone.

Which menopause tests help? Is an at-home FSH test useful?

Home tests measure FSH, or follicle-stimulating hormone. A positive result does not confirm menopause, and a negative result does not rule out perimenopause. The test does not show fertility or tell you when contraception can stop. After age 45, NICE usually recommends clinical identification without routine hormone tests.

Can I still become pregnant, and when can I stop contraception?

Ovulation can still occur during perimenopause, and HRT is not contraception. Do not stop contraception because of symptoms or a home test. Timing depends on age, the method used and the date of the last natural period, so agree it with a doctor or pharmacist.

Can I start hormone therapy (HRT) during perimenopause?

Yes, if symptoms are troubling and treatment is suitable for you. You do not need to wait for 12 months without a period. The regimen depends on whether you have a uterus, your cycle pattern, medical history and preferences.

Does menopause or HRT cause weight gain?

IMS says HRT has no direct effect on midlife weight. It may have small favourable effects on body composition, but it is not prescribed for weight loss or body reshaping. Weight and fat distribution can change because of age, sleep, activity, medicines and hormonal changes; some people notice temporary fluid retention.

How quickly does HRT help, and how long can I use it?

Some symptoms may improve within a few weeks; the full effect can take up to 3 months. NICE recommends a review at 3 months and then annually. There is no single duration for everyone: benefits, risks and the need to continue are reviewed, and symptoms may return after stopping.

What bleeding is usual after starting HRT?

For people with a uterus, vaginal bleeding can be common during the first 6 months of systemic HRT or during the first 3 months after changing the dose or preparation. Seek prompt medical help if it occurs beyond these timeframes. Outside those patterns, and with any very heavy bleeding, bleeding after 12 months without a period needs prompt assessment.

Can I use HRT if I have migraine, clot risk or a history of cancer?

These medical histories change the discussion, but they do not all have the same answer. Transdermal treatment through a patch, gel or spray may matter for clot risk, and a personal history or high risk of breast cancer requires individualised options and menopause expertise. Tell your clinician about migraine, blood pressure, liver disease, clots, cancer, heart disease or stroke before choosing treatment.

Can vaginal dryness, painful sex, urinary symptoms or low desire be treated?

Yes. Vaginal moisturisers, lubricants and low-dose vaginal oestrogen have different roles, and symptoms may return if local treatment stops. Sexual desire can be affected by pain, sleep, mood, relationships and medicines. NICE says testosterone can be considered for low sexual desire associated with menopause when HRT alone has not helped; NICE notes that when the recommendation was made, this was an off-label use.

Does brain fog mean dementia is starting?

Concentration problems and forgetfulness are commonly reported during the transition and do not establish a dementia diagnosis. Poor sleep, depression, anxiety, thyroid disease, anaemia and medicines can contribute. Progressive or severe change, or change affecting safety, deserves assessment. HRT is not prescribed to prevent dementia.

Are ‘bioidentical’ hormones or natural supplements safer?

Unregulated compounded hormones sold as ‘bioidentical’ have not been shown to be safer or more effective than authorised medicines; dose, purity and safety may be uncertain. Authorised medicines containing hormones identical to human hormones are a different category. Herbal products can interact with other medicines, so discuss them with a doctor or pharmacist.

What should I monitor for long-term health?

Keep up with screening recommended for your age and history. Routine appointments can cover blood pressure, cardiovascular and diabetes risk, bone health, fractures, muscle strength, smoking, alcohol and physical activity. Tests are chosen according to personal risk factors and national recommendations.

Does HRT cause breast cancer?

HRT is not a single treatment. Combined HRT raises breast cancer risk, and the increase is greater with longer use. NICE describes little or no increase with oestrogen alone. Personal risk also depends on age, family history, alcohol, weight and medical history; the comparison per 1,000 women above shows the estimated magnitude and does not predict an individual outcome.

At what age does menopause start, and when is it called early?

Usually between 45 and 55. Between 40 and 44 it is called early menopause. Under 40, symptoms and absent or infrequent periods may point to premature ovarian insufficiency; NICE recommends confirming it with raised FSH on two blood tests taken 4 to 6 weeks apart. Menopause can also come earlier after removal of the ovaries, chemotherapy or radiotherapy.

Is bleeding after menopause normal?

No. Any vaginal bleeding after at least 12 months without a period needs a doctor to assess it, even if it is light or happens once. The exception is systemic HRT in women with a uterus: some sequential regimens include planned bleeds, and bleeding can be common in the first 6 months or in the first 3 months after a change of dose or preparation. After those windows, unscheduled bleeding needs prompt checking.

Further reading

Where to continue.

Tools and reading that can help with orientation, appointment preparation and understanding the experience.

These resources complement the guide. Books and apps reflect their authors' selection, perspective and sometimes commercial activity; they do not have the status of clinical guidance and do not replace personalised medical advice.

Free clinical information

NHS: menopause and perimenopause

A clear starting point on symptoms, diagnosis, treatment, contraception and bleeding.

Open resource
Free clinical information

Women's Health Concern: practical factsheets

Factsheets on symptoms, HRT, vaginal health, bones and other topics, reviewed by the British Menopause Society medical advisory council.

Open resource
Practical tool

Balance

An app for tracking symptoms and generating a summary that can be used at an appointment.

This is a commercial English-language product created by Dr Louise Newson's team. It may include paid features, does not diagnose and does not replace medical care.
View the app
Reading

Four different perspectives.

Choose according to the question that concerns you, rather than the idea of a single 'definitive' book.

The Menopause Brain

Lisa Mosconi, PhD

For the relationship between hormonal change, the brain, memory, sleep and cognitive health.

Publisher page

The New Menopause

Mary Claire Haver, MD

A broad view of symptoms, midlife health, appointment preparation and treatment options.

Publisher page

The Definitive Guide to the Perimenopause and Menopause

Dr Louise Newson

A practical guide to stages of the transition, symptoms and HRT. The author also founded the team behind the Balance app.

Publisher page

Menopausing

Davina McCall & Dr Naomi Potter

Recognisable experiences and accessible explanations, also useful for conversations with family or a partner.

Publisher page

The resources above are in English. Links lead to the organisations, app or publishers concerned, with no commercial affiliation.

Evidence and limits

Where the information comes from.

This guide synthesises clinical guidance and official patient information. It does not replace medical assessment or confirm availability of every treatment in Romania. European authorisation (EMA, 7 December 2023) alone does not prove stock in a Romanian pharmacy or the local prescribing pathway: on 23 October 2026 current stock could not be confirmed from accessible Romanian official sources, so check availability with your doctor or pharmacy.

Search15 July 2026, rechecked on 27 September 2026
Main guidelinesNICE 2026 · ESE 2025
JurisdictionsUnited Kingdom · European Union
Clinical reviewNot yet checked by an independent doctor
01

NICE · Menopause: identification and management (NG23)

Definitions, diagnosis, management, HRT benefits and risks. Updated 15 April 2026; testosterone note reinstated in August 2026.

Open
02

European Society of Endocrinology · Clinical Practice Guideline

Evaluation and management of menopause and perimenopause in Europe. Published 13 October 2025.

Open
03

NHS · Menopause and perimenopause

Public information on symptoms, treatment, contraception and bleeding. Reviewed May 2026.

Open
04

EMA · Veoza (fezolinetant)

European authorisation, product information and warning on liver injury and liver-function monitoring.

Open
05

FDA · Menopause home-use tests

What at-home FSH tests measure and why they do not confirm menopause, fertility or when contraception can stop on their own.

Open
06

NICE · HRT discussion aid

Absolute risks per 1,000 people for breast, ovarian and endometrial cancer, cardiovascular outcomes, fractures and dementia.

Open
07

International Menopause Society · Brain fog in menopause

Clinical white paper on memory, attention, contributing symptoms, dementia concerns and brain health in midlife.

Open
08

NHS · Menopause for partners

A guide for partners on changing symptoms, sleep, patience and practical support.

Open
09

International Menopause Society · 2026 Recommendations

Midlife weight, body composition, abdominal fat, metabolic health and the role of HRT.

Open
10

Avis and colleagues · Duration of vasomotor symptoms (SWAN)

JAMA Internal Medicine, 2015. 1,449 US women with frequent hot flushes: median total duration 7.4 years, 4.5 years after the last period.

Open

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